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and other high income countries may have declined from the 1970s to 2018, 337 , 348 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 435 , 437 , 438 , 439 , 440 , 441 though results are mixed

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dissected intracellular NADPH sources, finding that PPP is the largest contributor to NADPH production, while ME1 and IDH2 appeared to be backups [125]